The molecular basis of recombination variation using linked-read sequencing technology

Genetic variation is the basis of biodiversity, and is the key substrate of evolution. We are studying meiotic recombination, a key source of genetic variation, to elucidate on the role it plays while organisms adapt to new environments. Using linked-read genome sequencing technology, we have developed a method of studying recombination in individuals, and are using this to identify its molecular basis. Research on this fundamental process has implications for our understanding of first trimester abortion, genome function and how molecular mechanisms shape evolution in natural populations.