Positions Available

 


 

 

Postdoctoral position in complex trait genetics and tissue engineering

A postdoctoral position in complex trait genetics and tissue engineering is available in the Chan Lab at the Max Planck Institute in Tübingen, Germany as part of a Max Planck and ERC-funded research team investigating gene network evolution in mouse tissue culture models.

 


Your role:  You will be the main driver in our exciting new project in studying gene network evolution using in vitro crosses of tissues from interspecific mouse hybrids. You will be responsible for the derivation of specialized embryonic stem cell and iPSC lines and the generation of recombinant inbred mapping panels from these lines. You will adopt tissue engineering techniques to assay expression and tissue phenotypes. You will analyze DNA and RNAseq data to dissect the genetic architecture of gene expression evolution in mouse tissue and organoid models. You will have the opportunity to develop independent research ideas within our mouse in vitro cross framework.

Requirements: You will have a PhD or equivalent degree in the areas of genetics, molecular biology or regenerative medicine. You should demonstrate expertise and experience in tissue engineering techniques. We are looking for a strong track-record and demonstrated excellence in creative and interdisciplinary thinking. A strong bioinformatics or statistical background will be advantageous. A background in evolutionary biology will be helpful, but not a requirement. We are interested in candidates who are keen to apply and develop new genetic tools and technologies. Passion for research, team spirit and enthusiasm are essential.

Our Team: We are a multidisciplinary team that focuses on the systems biology of development and evolution in mice, combining population and functional genomics with molecular biology and tissue engineering techniques to study the evolution of gene regulatory network in mouse and its close relatives. Our research group is funded by the European Research Council (ERC) and the Max Planck Society and is located on the Max Planck campus in Tübingen, Germany. Our campus hosts world-class research groups and operates state-of-the-art sequencing and other core facilities. English is the working language. All seminars and communications are in English.

Our Offer: The position is available for an initial 2 years with the possibility of extension based on performance. Salary and benefits are according to the German public service pay scale (TVöD Bund up to and including E13) and are commensurate with training and experience.

The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.

See Lazzarano et al., Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells. Proc Nat Acad Sci, 2018. doi: 10.1073/pnas.1717474115

To Apply: Consideration of applications will begin on 15th April 2018, and will remain open until filled. Please send your application with 1. a statement of research interests and why you have applied for this position, 2. your CV, and 3. three reference letters to Dr Frank Chan at frank.chantue.mpg.de or the postal address below. Incomplete applications will not be considered.   

 

Dr Frank Chan, Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, 72076 Tübingen, Germany.

 



 

 

Staff scientist in tissue engineering and molecular biology 

A staff scientist position in tissue engineering and molecular biology is available in the Chan Lab at the Max Planck Institute in Tübingen, Germany as part of a Max Planck and ERC-funded research team investigating gene regulatory network evolution in mouse and human tissue culture models.

 


Your role:  You will be a central team member assigned to work closely with a postdoc in carrying out work mainly using tissue culture, tissue engineering and microfluidics techniques. You will be responsible for the derivation and maintenance of specialized iPS and embryonic stem cell lines, creation of cell line panels using the in vitro recombination technique developed by our laboratory (see Lazzarano et al., 2018). You will be trained to apply tissue engineering techniques, including but not limited to flow or microfluidics models to assay expression and tissue phenotypes. You will also operate flow cytometry instrument in the context of tissue differentiation and single-cell studies. You will assist in generating DNA and RNAseq libraries to help dissect the genetic architecture of gene expression evolution in mouse or human tissue models.

Requirements: You should hold a Bachelors-equivalent degree or higher qualifications in the areas of genetics, molecular biology or regenerative medicine. We are looking for a strong track-record and demonstrated research experience and training, particularly in tissue culture and aseptic techniques. Passion for research, team spirit and enthusiasm are essential. English is required.

Our Team: We are a multidisciplinary team that focuses on the systems biology of development and evolution in mice, combining population and functional genomics with molecular biology and tissue engineering techniques to study the evolution of gene regulatory network in mouse and its close relatives. Our research group is funded by the European Research Council (ERC) and the Max Planck Society and is located on the Max Planck campus in Tübingen, Germany. Our campus hosts world-class research groups and operates state-of-the-art sequencing and other core facilities. English is the working language. All seminars and communications are in English.

Our Offer: The position is available for an initial 2 years with the possibility of extension based on performance. Salary and benefits are according to the German public service pay scale (TVöD Bund up to and including E13) and are commensurate with training and experience.

The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.

See Lazzarano et al., Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells. Proc Nat Acad Sci, 2018. doi: 10.1073/pnas.1717474115

 

To Apply: Consideration of applications will begin on 15th April 2018, and will remain open until filled. Please send your application with 1. a statement of research interests and why you have applied for this position, 2. your CV, and 3. three reference letters to Dr Frank Chan at frank.chantue.mpg.de or the postal address below. Incomplete applications will not be considered.   

 

Dr Frank Chan, Friedrich Miescher Laboratory of the Max Planck Society, Max-Planck-Ring 9, 72076 Tübingen, Germany.

 


Weir Lab: Structural Biochemistry of Meiosis

 

We are looking for a PhD student to join our new group at the Friedrich Miescher Laboratory on the Max Planck Campus in Tuebingen, southern Germany.

 

                                                                  We

·       Are interested in understanding molecular mechanisms in early meiosis

·       Take a bottom up approach, building meiotic machines from scratch to understand them in detail

·       Use a combination of protein biochemistry, structural biology and yeast genetics

·       Are a small lab offering close supervision and support at this pivotal stage in your career

·       Are generously funded by the Max Planck society, one of the world’s most successful basic research organisations

·       Have in-house access to

o   Extensive protein expression and purification set-up

o   EM and Cryo-EM core facilities

o   X-ray (in-house robotics and regular synchrotron beam time)

o   NMR facility

o   Light microscopy facility

o   Excellent biophysical instrumentation (e.g. ITC, MST)

·       Are located in the picturesque yet lively town of Tuebingen, where students make up over 30% of the population

 

You

·       Are interested in understanding how molecular machines work

·       Enjoy working both on your own and as part of a team

·       Appreciate detailed problem solving

·       Would like to visit international conferences and present your data

·       Have some background in either structural biology or biochemistry

·       Would like to broaden your knowledge and expertise including extensive transferable skills

·       Have a Masters degree or a Bachelors degree plus relevant research experience

 

Apply

Please send a letter detailing why you would like to join our lab, plus your CV to John Weir (john.weir[at]tuebingen.mpg.de) by January 30th 2017 at the latest (earlier applications will be considered first).

The Max Planck Society is committed to employing more disabled individuals and especially encourages them to apply. Furthermore the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

 

 

weirlab.com