Patrick Mueller

Position: Research Group Leader
Address: Max-Planck-Ring 9
72076 Tübingen
Phone: +49 7071 601 815
E-Mail: patrick.mueller[at]
Picture of Mueller, Patrick

Curriculum Vitae

since 2014 Max Planck Research Group Leader at the FML
2013-2014 Emmy Noether Independent Research Group Leader at the MPI for Developmental Biology
2007-2013 Postdoctoral Fellow and Research Associate at Harvard University
2004-2007 Ph.D. studies at the MPI for Biophysical Chemistry
1999-2004 Diploma studies in Göttingen, Berkeley, New York

Selected honors

2017 EMBO Young Investigator Award


ERC Starting Grant


HFSP Career Development Award
2013-2014 Emmy Noether Program Award
2008-2011 HFSP long-term postdoctoral fellowship
2008 Otto Hahn Medal of the Max Planck Society
2007-2008 EMBO long-term postdoctoral fellowship
2003-2006 German National Academic Foundation (Studienstiftung des Deutschen Volkes) undergraduate and graduate fellowships
2002-2003 International Max Planck Research School Scholarship
2001-2002 University of California Education Abroad Program

Selected publications
Mörsdorf D, Müller P (2019). Tuning protein diffusivity with membrane tethers. Biochemistry, 58:177-181.


Rogers KW, Müller P (2019). Nodal and BMP dispersal during early zebrafish development. Developmental Biology, 447:17-23.


Almuedo-Castillo M, Bläßle A, Mörsdorf D, Marcon L, Soh GH, Rogers KW, Schier AF, Müller P (2018). Scale-invariant patterning by size-dependent inhibition of Nodal signalling. Nature Cell Biology, doi: 10.1038/s41556-018-0155-7.


Soh GH, Müller P (2018). FRAP analysis of extracellular diffusion in zebrafish embryos. Methods Mol Biol, 1863:107-124.


Piragyte I, Clapes T, Polyzou A, Geltink RIK, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E (2018). A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature Communications, doi: 10.1038/s41467-018-05311-4.


Diego X, Marcon L, Müller P, Sharpe J (2018). Key features of Turing systems are determined purely by network topology. Phys. Rev. X, 8, 021071.

Bläßle A, Soh G, Braun T, Mörsdorf D, Preiß H, Jordan BM, Müller P (2018). Quantitative diffusion measurements using the open-source software PyFRAP. Nature Communications, doi: 10.1038/s41467-018-03975-6.

Ramachandran A, Vizan P, Debipriya D, Chakravarty P, Vogt J, Rogers KW, Müller P, Hinck AP, Sapkota GP, Hill CS (2018). TGF-beta uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition. eLife, doi: 10.7554/eLife.31756.


Pomreinke AP, Soh GH, Rogers KW, Bergmann JK, Bläßle AJ, Müller P (2017). Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning. eLife, doi: 10.7554/eLife.25861.


Donovan P, Dubey OA, Kallioinen S, Rogers KW, Muehlethaler K, Müller P, Rimoldi D, Constam DB (2017). Paracrine Activin-A signaling promotes melanoma growth and metastasis through immune evasion. J Invest Dermatol, doi: 10.1016/j.jid.2017.07.845.


Marcon L, Diego X, Sharpe J, Müller P (2016). High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals. eLife, doi: 10.7554/eLife.14022.

Sako K, Pradhan SJ, Barone V, Inglés-Prieto Á, Müller P, Ruprecht V, Capek D, Galande S, Janovjak H, Heisenberg CP (2016). Optogenetic control of Nodal signaling reveals a temporal pattern of Nodal signaling regulating cell fate specification during gastrulation. Cell Reports, doi: 10.1016/j.celrep.2016.06.036.


Müller P, Nüsslein-Volhard C (2016). Obituary: Hans Meinhardt (1938-2016). Development, 143:1231-1233.


Bläßle A, Müller P (2015). PyFDAP: Automated analysis of Fluorescence Decay After Photoconversion (FDAP) experiments. Bioinformatics, 15:972-974.


Rogers KW, Bläßle A, Schier AF, Müller P (2015). Measuring protein stability in living zebrafish embryos using Fluorescence Decay After Photoconversion (FDAP). J Vis Exp, 95:52266.


Müller P, Rogers KW, Shuizi RY, Brand M, Schier AF (2013). Morphogen transport. Development, 140:1621-1638.

Müller P, Rogers KW, Jordan BM, Lee JS, Robson D, Ramanathan S, Schier AF (2012). Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system. Science, 336:721-724.

Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI (2012). Nanog Regulates Endoderm Formation through the Mxtx2-Nodal Pathway. Dev Cell, 22:625-638.

Müller P, Pugazhendhi D, Zeidler MP (2012). Modulation of human JAK/STAT pathway signalling by functionally conserved regulators. JAK-STAT, 1:34-43.

Müller P, Schier AF (2011). Extracellular movement of signaling molecules. Dev Cell, 21:145-158.

Müller P, Boutros M, Zeidler MP (2008). Identification of JAK/STAT pathway regulators - Insights from RNAi screens. Semin Cell Dev Biol, 19:360-369.

Ginsberg M, Czeko E, Müller P, Ren Z, ChenX, Darnell JE Jr. (2007). Amino acid residues required for physical and cooperative interaction of STAT3 and AP-1 proteins c-Jun and c-Fos. Mol Cell Biol, 27:6300-6308.

Dietz GP, Valbuena C, Dietz B, Meuer K, Müller P, Weishaupt JH, Bähr M (2006). Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson’s disease. Brain Res, 1082:61-66.

Müller P, Kuttenkeuler D, Gesellchen V, Zeidler MP, Boutros M (2005). Identification of JAK/STAT signaling components by genome-wide RNA interference. Nature, 436:871-875.