Chan Lab: The molecular and genomic basis of adaptation

Chan, Jones and Valenzano Labs (MPI Ageing/Cologne - not in picture) joint retreat on the doorstep to Austria (background mountains)

 

Lab news

Longshanks paper accepted at eLife


20.May.2019 - It's now official! Our Longshanks manuscript is now accepted at eLife! Thank you Campbell, and all the co-authors! 

Frank @ Cornell

14.May.2019 - Frank gives a talk at 3CPG at Cornell. Is Ithaca gorgeous? 

ESEB 2019

03.May.2019 - Congralutions to João for getting a talk at ESEB in Turku this coming August! EvoDevo of leg length evolution! Check it out at the meeting! Layla's going to represent the lab there as well!

Layla, SMBE Manchester award and talk

03.May.2019 - Congratulations to Layla for getting a Young Investigator Travel Award at SMBE 2019! Go catch her talk!

Frank and Felicity double-header at Stanford

17.04.2019 - What a home-coming! Frank gave a talk at the Stanford DevBio/Genetics/Biochem Frontiers series on the Longshanks mice, HybriMiX, and haplotagging, right after Felicity's talk on the StickleCODE and recombination rate evolution in EvolGenome.

 

Layla - talk at SMBE@Vienna

13.02.2019 - Congratulations to Layla for giving a great Opens external link in new windowtalk at SMBE@Vienna on the selection trajectories in 1600 Longshanks mice!

João - PhD Symposium Oral Presentation Award

22.Nov.2018 - Congratulations to João for rocking it at the 2018 PhD Symposium! 

Pitx1 paper at eLIFE


04.12.2018 - Blast from the past - new paper on mouse hind limb factor Pitx1. Thanks to the hard work by first author Abbey Thompson (PhD student, Kingsley Lab) and many others in the Kingsley Lab who kept digging at it! doi: Opens external link in new window10.7554/eLife.38555

HybridMiX paper out at PNAS!


21.03.2018 - Our first paper on HybridMiX is now online early at PNAS! Great work HybridMiX team! doi: 10.1073/pnas.1717474115

Frank @ Zürich

16.May.2017 - Frank visits the Institute of Pharmacology Toxicology at UZH

Edinburgh!

17.03.2017 - Frank talks limb development and regulation at IGMM, and then the success (or lack thereof!) of modelling with a keynote at the Complex Trait Alliance crowd. All models are wrong. Some are useful. Hmm...

Frank, CRUK @ Cambridge

05.Jan.2017 - Frank visits Cancer Research UK and talks about HybridMiX

GenEV(e)

02.Dec.2016 - Frank tells the enthusiastic Geneva crowd in the aptly named GENEVolution department about the latest on the HybridMiX project. 

ERC StG!


28.11.2014 - This just in: we have been awarded an ERC Starting Grant!!! With this funding we can launch our project HybridMiX to study gene regulatory network evolution and speciation[!] in mice by performing "in vitro" crosses on stem cells. Stay tuned!

Feature in NatureJobs


02.10.2014 - How do you staff a lab? It takes the right mix. Chris Woolston tries to find out and Frank gave his perspective for starting a lab at the FML. Read it here.

Paper in Nature


17.07.2014 - Our contribution to an innovative study of the genetic basis of ecological speciation in a classical "species pair" in sticklebacks appears in Nature! Read the Opens external link in new windowpaper
Image credit: Todd Hadfield

Research Focus


Organisms exhibit an enormous diversity of adaptations in accordance with their evolutionary niche. We want to understand how complex adaptations are encoded in the vertebrate genome. Using the house mouse as our model organism, we aim to uncover and connect molecular innovations to their phenotypic outcomes. In doing so, we link evolutionary adaptations from their molecular origins to whole organisms and populations.
In our group we combine a number of experimental systems to tackle this question.
Photo credit: Lutz Bünger
Photo credit: Lutz Bünger
 
Genes - Parallel evolution of gigantism in lab and wild mice
 
We investigate how response to selection for increased body weight in mice reshapes the gene regulatory network in the genome. Using long-term artificially selected mice for increased body weight and naturally evolved island gigantic mice, we compare and contrast various evolutionary strategies for tweaking this complex gene regulatory network.
 
 
 
Genomes - Population genomics of hybridization and adaptation
 
We also investigate how genomes reshapes itself on the fly in response to selection by tracking genomes during adaptation. We track the fates of individual gene variants and how it spreads in a population, such that an adaptive allele can rise to high frequency and produce evolutionary changes.
 
Montage from photos by Patrick Gries 
Montage from mammalian (and others) adaptations photos by Patrick Gries in Opens external link in new windowEvolution.
 
Species - Comparative genomics of mammalian adaptations
We investigate the nature of adaptive mutations at the molecular level, by taking advantage of advances in genomics and transgenic techniques. We will do so by exploring the diversity of newly available genomes to engineer mice to carry presumptive adaptive mutations and test how they may functionally produce adaptations.
 

Join the lab! Open positions available for exciting and cutting-edge Diploma, PhD and postdoctoral projects
 
 

Funding

We are grateful to the following funding sources for supporting our research.
 
 
We have also benefited from the generosity of the following sources for staff funding (both current and recent):