Molecular networks controlling chromosome segregation
Life depends on the correct propagation of genetic material from one generation to the next. Errors in the distribution of chromosomes can result in cell death, contribute to tumorigenesis or, when happening in germ cells, lead to abortion or birth defects. We study the protein networks controlling chromosome segregation and want to understand how the wiring of these networks and the interplay of their components influence the features of the process. Since chromosome segregation is fundamental for life, many of the basic components and principles are conserved throughout evolution. We use fission yeast, S. pombe, a small unicellular eukaryote whose genome can be easily modified, as a model organism and we combine advanced fluorescence microscopy with other cell biological, genetic and biochemical methods.