Positions Available

 


 

 

Postdoctoral position in complex trait genetics and computational genomics

 

A postdoctoral position in complex trait genetics and computational genomics is available in the Chan Lab at the Max Planck Institute in Tübingen, Germany as part of a Max Planck and ERC-funded research team investigating gene regulatory network evolution in mouse and human tissue culture models.

 


The key innovation in the HybridMiX project is the development of in vitro recombination (IVR) in tissue culture, specifically in F1 interspecific hybrid mouse ES cells for genetic mapping (see Lazzarano et al., PNAS, 2018). IVR allows us to create recombinant cell lines across species of effectively unlimited panel size, at low costs and . We now aim to map the evolutionary divergence between mouse species at the tissue and cellular level by generating interspecific panels and obtaining their phenotypes via tissue engineering, organ-on-a-chip or droplet microfluidic single-cell methods.

Your role:  You will be leading our computational lead in analyzing large mapping datasets derived from genomics and functional assays from our IVR panels. You will map and identify genetic variation that contribute to differences between mouse species. You will also integrate such individual differences to changes in the gene regulatory network. You will have the opportunity to work with unique single-cell or single-molecule datasets to detect mitotic recombination events and connect such changes to the cell fates in cell lines or whole organisms. 

Requirements: You will have a PhD or equivalent degree in the areas of statistical, functional or quantitative genomics. You should have a strong background in analyzing genomic data and the proficiency to handle large datasets, (e.g. skills in Unix, R and scripting or programming languages). In our projects we routinely integrate information from diverse sources, including single-cell, linked-read, chromosome conformation capture, as well as image analysis to assist with our analyses of cellular and tissue-level phenotypes and genotypes. Passion for research, team spirit and enthusiasm are essential. English is required.

Our Team: We are a multidisciplinary team that focuses on the systems biology of development and evolution in mice, combining population and functional genomics with molecular biology and tissue engineering techniques to study the evolution of gene regulatory network in mouse and its close relatives. Our research group is funded by the European Research Council (ERC) and the Max Planck Society and is located on the Max Planck campus in Tübingen, Germany. The Max Planck Tübingen Campus is a highly innovative research hub with world-class genomics and machine learning expertise. Our sequencing core features the Illumina, PacBio and 10X Genomics platforms. English is the working language. All seminars and communications are in English.

Our Offer: The position is available for an initial 2 years with the possibility of extension based on performance. Salary and benefits are according to the German public service pay scale (TVöD Bund up to and including E13) and are commensurate with training and experience.

The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.

To Apply: Consideration of applications will begin on 1st Dec 2018. The projected start date is in early 2019 but can be negotiable. Please send your informal enquires or application to Dr Frank Chan at frank.chantue.mpg.de. 

Complete applications should include: 1. a statement of research interests and why you have applied for this position, 2. your CV, and 3. three reference letters

 

Publication: Lazzarano et al., Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells. Proc Nat Acad Sci, 2018. doi: 10.1073/pnas.1717474115

 

 



 

 

Postdoctoral position in stem cell genomics and tissue engineering

 

 

A postdoctoral position in complex trait genetics and tissue engineering is available in the Chan Lab at the Max Planck Institute in Tübingen, Germany as part of a Max Planck and ERC-funded research team investigating gene network evolution in mouse tissue culture models.

 


The key innovation in the HybridMiX project is the development of in vitro recombination (IVR) in tissue culture, specifically in F1 interspecific hybrid mouse ES cells for genetic mapping (see Opens external link in new windowLazzarano et al., PNAS, 2018). IVR allows us to create recombinant cell lines across species of effectively unlimited panel size, at low costs and within a matter of weeks. We now aim to map the evolutionary divergence between mouse species at the tissue and cellular level by generating interspecific panels and obtaining their phenotypes via tissue engineering, organ-on-a-chip or droplet microfluidic single-cell methods.

Your role:  You will be the main driver in our exciting new project in studying gene network evolution using in vitro crosses of tissues from interspecific mouse hybrids. You will adopt tissue engineering techniques to assay expression and tissue phenotypes. You will analyze DNA and RNAseq data to dissect the genetic architecture of gene expression evolution in mouse tissue and organoid models. You will have the opportunity to develop independent research ideas within our mouse in vitro cross framework.

Requirements: You will have a PhD or equivalent degree in the areas of genetics, molecular biology or regenerative medicine. You should demonstrate expertise in tissue culture techniques, especially in the area of differentiation or flow-based cultures. Alternatively you may be familiar with single-cell techniques and with performing functional genomics experiments such as RNAseq, ATACseq and ChIPseq. We are looking for a strong track-record and demonstrated excellence in creative and interdisciplinary thinking. A strong bioinformatics or statistical background will be advantageous. A background in evolutionary biology will be helpful, but not a requirement. We are interested in candidates who are keen to apply and develop new genetic tools and technologies. Passion for research, team spirit and enthusiasm are essential.

Our Team: We are a multidisciplinary team that focuses on the systems biology of development and evolution in mice, combining population and functional genomics with molecular biology and tissue engineering techniques to investigate the evolution of complex genomes like the mouse. Our research group is funded by the European Research Council (ERC) and the Max Planck Society and is located on the Max Planck campus in Tübingen, Germany. The Max Planck Tübingen Campus is a highly innovative research hub with world-class genomics and machine learning expertise. Our sequencing core features the Illumina, PacBio and 10X Genomics platforms. English is the working language. All seminars and communications are in English.

Our Offer: The position is available for an initial 2 years with the possibility of extension based on performance. Salary and benefits are according to the German public service pay scale (TVöD Bund up to and including E13) and are commensurate with training and experience.

The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply.

To Apply: Consideration of applications will begin on 1st Dec 2018. The projected start date is in early 2019 but can be negotiable. Please send your informal enquires or application to Dr Frank Chan at frank.chantue.mpg.de. 

Complete applications should include: 1. a statement of research interests and why you have applied for this position, 2. your CV, and 3. three reference letters

 

Publication: Lazzarano et al., Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells. Proc Nat Acad Sci, 2018. doi: 10.1073/pnas.1717474115.

 


Weir Lab: Structural Biochemistry of Meiosis

 

We are looking for a PhD student to join our new group at the Friedrich Miescher Laboratory on the Max Planck Campus in Tuebingen, southern Germany.

 

                                                                  We

·       Are interested in understanding molecular mechanisms in early meiosis

·       Take a bottom up approach, building meiotic machines from scratch to understand them in detail

·       Use a combination of protein biochemistry, structural biology and yeast genetics

·       Are a small lab offering close supervision and support at this pivotal stage in your career

·       Are generously funded by the Max Planck society, one of the world’s most successful basic research organisations

·       Have in-house access to

o   Extensive protein expression and purification set-up

o   EM and Cryo-EM core facilities

o   X-ray (in-house robotics and regular synchrotron beam time)

o   NMR facility

o   Light microscopy facility

o   Excellent biophysical instrumentation (e.g. ITC, MST)

·       Are located in the picturesque yet lively town of Tuebingen, where students make up over 30% of the population

 

You

·       Are interested in understanding how molecular machines work

·       Enjoy working both on your own and as part of a team

·       Appreciate detailed problem solving

·       Would like to visit international conferences and present your data

·       Have some background in either structural biology or biochemistry

·       Would like to broaden your knowledge and expertise including extensive transferable skills

·       Have a Masters degree or a Bachelors degree plus relevant research experience

 

Apply

Please send a letter detailing why you would like to join our lab, plus your CV to John Weir (john.weir[at]tuebingen.mpg.de) by January 30th 2017 at the latest (earlier applications will be considered first).

The Max Planck Society is committed to employing more disabled individuals and especially encourages them to apply. Furthermore the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

 

 

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