POSITION AVAILABLE IN
BIOINFORMATICS AND EVOLUTIONARY GENOMICS
The Jones Lab at the Friedrich Miescher Laboratory located on the Max Planck Campus, Tübingen, Germany, is looking for a talented researcher with skills in bioinformatics, statistical genetics, computer science, and/or evolutionary genomics to work on project exploring genome evolution in adaptively diverging species. The position is available for an initial 2 years with the possibility of extension (Postdoc level) or the duration of a PhD project.
We work at the cross-section between functional and evolutionary genomics with the aim of understanding the molecular mechanism and evolutionary processes underlying phenotypic variation, adaptation and speciation using stickleback fish. The Jones Lab is funded by the Max Planck Society, German Research Council and holds a prestigious European Research Council Consolidator Grant.
We are looking to recruit a talented and motivated bioinformatician to perform comparative analysis of functional elements in the genomes of diverging species. You will work closely with data generated by wet-lab team members with a focus on comparing the genomic divergence in functional elements in marine and freshwater sticklebacks (including comparisons of de novo assemblies). Where applicable you may also participate actively in wet-lab data generation using our established high-throughput robotics platforms.
Comparative Functional Genomics and Genome Evolution
Which parts of the genome are used during adaptation and speciation? How does the genome evolve? Taking advantage of long-read sequencing technologies you will build de novo genome assemblies of multiple divergent stickleback ecotypes. You will identify and annotate functional elements underlying adaptation and speciation by integrating ChIP-seq, CaptureC conformational interactions, RNAseq and signatures of selection from whole genome datasets. In addition you will pinpoint loci contributing to adaptive divergence and genetic incompatibilities between species using statistical genetic and population genomic analyses of sequenced families and wild individuals. You will be using data visualisation techniques for display and interaction with the functional genomic annotations. Working with other wetlab-based team members this project offers the opportunity for validation of functional elements using various transgenic and molecular biology assays.
Requirements: We invite applications for the above positions at postdoctoral or PhD levels (MSc or 4-year BSc required). You will have training in genomics, bioinformatics and/or evolutionary genetics and in-depth research experience in these fields. You should demonstrate expertise and proficiency in one or more of the following areas:
● de novo genome assembly (eg using PacBio, Illumina sequence data, graph-based assembly algorithms etc.)
● handling and analysis of NGS datasets (whole genome, ChIP-seq, RNA-seq, ATAC-seq, 3C/4C)
● handling large-scale computational data
● familiarity with visualisation of genomic datasets and associated toolkits (e.g. UCSC/Ensembl genome browsers, proficiency with web-based programming and SQL relational databases desirable)
● evolutionary genomics (eg empirical or theoretical population genomics)
● advanced skills in statistical analysis (e.g. genotype imputation, Hidden Markov Models, haplotype phasing of whole genome data, QTL or GWAS approaches)
Experience with UNIX and fluency in statistical and/or programming languages (R, Python or Perl, C++, SQL, java knowledge desirable) is essential. Wetlab skills and experience in other types of data analysis (e.g., image processing) will be an advantage.
We are interested in candidates who are keen to apply new and innovative statistical approaches. Passion for research, team spirit and enthusiasm are essential.
Our Team: You will work in a multidisciplinary team that focuses on applying genomics approaches to understand the functional basis of adaptation and speciation in mice and fish. Our research groups are funded by the Max Planck Society as well as the European Research Council (ERC) and the DFG. The Max Planck Campus in Tübingen, Germany is one of the leading campuses in evolutionary genomics research. Our campus hosts world-class research groups, including a Nobel laureate and >10 ERC-funded teams. We operate state-of-the-art sequencing and other core facilities. English is the working language. All seminars and communications are in English.
Our Offer: Positions at the Postdoc level will be initially offered for 2 years, with the possibility of extension. Funding for PhD studentship is available for the entire duration. Positions will be supported by contracts with salary and benefits based on the German public service pay scale (TVöD) and are commensurate with training and experience. The Max Planck Society seeks to increase the number of women in areas where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society is committed to employing individuals with disabilities and especially encourages them to apply.
To Apply: Consideration of applications will begin on 1st May, 2016, and will remain open until filled. Please send your application with 1. a cover letter outlining your background, achievements and motivations; 2. your CV, and 3. two reference contacts to Dr. Felicity Jones (firstname.lastname@example.org) or the postal address below. Incomplete applications will not be considered.
Dr. Felicity Jones
Friedrich Miescher Laboratory of the Max Planck Society
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