Chan Lab: The molecular and genomic basis of adaptation

Chan, Jones and Valenzano Labs (MPI Ageing/Cologne - not in picture) joint retreat on the doorstep to Austria (background mountains)

 

Lab news

We are hiring!


25.04.2016 - We are hiring! If you are: innovative, driven and talented scientists who's looking to do ground-breaking research at a world-class research institute that combines stem cell biology, systems biology and evolutionary biology, we have a position for you! Two positions at the PhD or Opens internal link in current windowPostdoc levels are available. What are you waiting for? 

ERC StG!


28.11.2014 - This just in: we have been awarded an ERC Starting Grant!!! With this funding we can launch our project HybridMiX to study gene regulatory network evolution and speciation[!] in mice by performing "in vitro" crosses on stem cells. Stay tuned!

Feature in NatureJobs


02.10.2014 - How do you staff a lab? It takes the right mix. Chris Woolston tries to find out and Frank gave his perspective for starting a lab at the FML. Read it here.

Paper in Nature


17.07.2014 - Our contribution to an innovative study of the genetic basis of ecological speciation in a classical "species pair" in sticklebacks appears in Nature! Read the Opens external link in new windowpaper
Image credit: Todd Hadfield

Paloma


10.06.2013 - Welcome Paloma Medina, our summer undergraduate intern from sunny SoCal (Scripps College)!
Paloma will be spending this summer with us in Deutschland working on next generation sequence analysis from LARGE mice.
Unix fun!

Research Focus


Organisms exhibit an enormous diversity of adaptations in accordance with their evolutionary niche. We want to understand how complex adaptations are encoded in the vertebrate genome. Using the house mouse as our model organism, we aim to uncover and connect molecular innovations to their phenotypic outcomes. In doing so, we link evolutionary adaptations from their molecular origins to whole organisms and populations.
In our group we combine a number of experimental systems to tackle this question.
Photo credit: Lutz Bünger
Photo credit: Lutz Bünger
 
Genes - Parallel evolution of gigantism in lab and wild mice
 
We investigate how response to selection for increased body weight in mice reshapes the gene regulatory network in the genome. Using long-term artificially selected mice for increased body weight and naturally evolved island gigantic mice, we compare and contrast various evolutionary strategies for tweaking this complex gene regulatory network.
 
 
 
Genomes - Population genomics of hybridization and adaptation
 
We also investigate how genomes reshapes itself on the fly in response to selection by tracking genomes during adaptation. We track the fates of individual gene variants and how it spreads in a population, such that an adaptive allele can rise to high frequency and produce evolutionary changes.
 
Montage from photos by Patrick Gries 
Montage from mammalian (and others) adaptations photos by Patrick Gries in Opens external link in new windowEvolution.
 
Species - Comparative genomics of mammalian adaptations
We investigate the nature of adaptive mutations at the molecular level, by taking advantage of advances in genomics and transgenic techniques. We will do so by exploring the diversity of newly available genomes to engineer mice to carry presumptive adaptive mutations and test how they may functionally produce adaptations.
 

Join the lab! Open positions available for exciting and cutting-edge Diploma, PhD and postdoctoral projects
 
 

Funding

We are grateful to the following funding sources for supporting our research.
 
 
We have also benefited from the generosity of the following sources for staff funding (both current and recent):