Marion Weberruss and Wolfram Antonin (2016)

Perforating the nuclear boundary: how nuclear pore complexes assemble

Journal of Cell Science doi10.1242/jcs.194753


The nucleus is enclosed by the nuclear envelope, a double membrane which creates a selective barrier between the cytoplasm and the nuclear interior. Its barrier and transport characteristics are determined by nuclear pore complexes (NPCs) embedded within the nuclear envelope which control molecular exchange between the cytoplasm and nucleoplasm. In this commentary, we discuss the biogenesis of these huge protein assemblies from approximate one thousand individual proteins. We will summarize current knowledge about distinct assembly modes in animal cells that are characteristic for different cell cycle phases and their regulation.